A Link Between Loss of Smell and Alzheimer’s Disease
A study has revealed a link between a
declining sense of smell and mild cognitive impairment (MCI) and Alzheimer’s
disease. Researchers found that
neurodegeneration associated with Alzheimer’s has a notable effect on the brain
circuits that process our sense of smell.
The 2016 study was conducted by the
Massachusetts General Hospital and involved a group of 183 participants of
which 70 were cognitively normal and 74 tested normal on
cognitive tests but were concerned about their cognitive abilities. Another 29 had MCI and 10 had been diagnosed
with possible Alzheimer’s disease. Those
who performed more poorly on the olfactory tests were found more likely to have
the variant of the APOE gene, related to an increased risk of Alzheimer’s. One of the study’s authors, Mark Albers, MD,
PhD, assistant professor of neurology at Mass General Institute for
Neurodegenerative Disease, states, “There is increasing evidence that the
neurodegeneration behind Alzheimer’s disease starts at least 10 years before
the onset of memory symptoms.” Furthermore,
he stresses the benefit of an early diagnosis as the individuals can begin
appropriate therapeutic treatments.
Dr. Albers continues, “If these
results hold up, this sort of inexpensive, noninvasive screening could help us
identify the best candidates for novel therapies.” In addition, identifying the disease early
may also be instrumental in helping to develop effective treatments that will delay
and slow the progress of the disease.
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Source:
universityhealthnews.com/daily/memory/losing-sense-of-smell-is-early-sign-dementia/
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